 |
Figure 1. Components of Aloe.
Original Image Source: Click Here! |
Aloe vera belongs to the Liliaceal family and is one of the few Aloe species important for its medicinal use (Vogler & Ernst, 1999). It is postulated that aloe originated from South and East Africa, and then was brought over to areas such as North Africa, China and Spain (Haller, 1990). Aloe has a history of use since the ancient Egyptians, Biblical times and Mediterranean civilizations (Grindlay & Reynolds, 1986). The two parts of the aloe plant that are used medicinally are the aloe latex and the aloe gel. The aloe latex is a bitter yellow juice collected from the pericyclic cells beneath the plant skin. The aloe gel is colourless and obtained from the mucilaginous cells of the inner leaf (Klein & Penneys, 1988). Traditionally, the entire aloe vera leaf could be used, or the aloe latex dried and the gel collected to be used separately (Grindlay & Reynolds, 1986). Aloe was used in folk medicine as a laxative and for dermatological issues such as burns and wounds. It was not until the 19th century was evidence found to support aloe use through the discovery of aloin. Aloin is an active ingredient in aloe latex that can relieve constipation by increasing activity in the intestine and bowel. By the 20th century, it became very popular in the United States and there were numerous formulations of aloe laxatives taken in the form of pills. At this time, the use of aloe was not yet regulated. Later it was discovered that ingestion of aloe induced painful griping, and so the use of aloe as a laxative has decreased (Haller, 1990). On the countrary, more recently, the use of aloe gel for dermatological wounds has increased in popularity (Grindlay & Reynolds, 1986).
Posted in
aloe gel,
aloe latex,
Aloe vera,
aloin,
History,
Introduction,
Traditional Use
 |
Figure 2. Chemical structure of acemannan.
Original Image Source: Click here!
|
The two main components of the aloe plant used is the aloe latex and aloe gel. There are many active constituents in aloe, including carboxypeptidase that inactivates bradykinin and reduces pain, salicylate that is an anti-inflammatory, and magnesium lactate that has anti-itching properties (Reynolds & Dweck, 1999). The more widely researched components are anthraquinones and acemannan. Anthraquinones are active phenolic compounds found in aloe latex with strong laxative properties, an example being aloin (Vogler & Ernst, 1999). Acemannan is a long chain β-(1,4)-linked galactomananan polymer found in the aloe gel (Zhang & Tizard, 1996). It has been found to enhance phagocytic activity in macrophages, thus having an effect on the immune system (Yates et al., 1992).
Aloe vera is administered as ointments, medicated creams, lotions, capsules or even as a tonic depending on its desired effects. Aloe gel preparation must now be FDA approved. Aloe is harvested manually, cleaned by hand or with a mild chlorine solution and filleted to remove the central gel. The gel is then filtered and put through a stabilization process to denature browning enzymes and preservatives may be added. After this process, the gel is often modified in different ways to serve different purposes (Grindlay & Reynolds, 1986).
 |
Source: (Vogler & Ernst, 1999) Box 1. Constituents of aloe. |
Posted in
acemannan,
active components,
aloe gel,
aloe latex,
Aloe vera,
aloin,
preparation
In terms of adverse effects, aloe gel is used in research experiments more often, and is generally regarded as safe with minimal side effects. In some rare cases, aloe has been found to cause allergic reactions when applied topically (Klein & Penneys, 1988). On the other hand, caution must be taken when administering aloe orally. Aloe latex as a laxative can cause diarrhea, abdominal pain and heart disturbances (Haller, 1990). It can be fatal if taken in large doses over several days. Also, as a laxative it may decrease the efficacy of other oral drugs. Aloe may lower blood sugar, so combined effects with other medications that also lower blood sugar such as antidiabetic drugs may be harmful. Aloe may also decrease blood clotting and increase the chances of bleeding, so it is advised to be cautious if blood thinners are being taken or before a surgical procedure. In regards to other herbs, as aloe is a laxative and when used with other herbs such as black root, jalap root and rhubarb root that also have laxative properties may be harmful. Also, herbs such as horsetail, liquorice and figwort that lower blood sugar levels in combination with aloe may be unsafe (MedlinePlus, 2010).
Posted in
adverse effects,
aloe gel,
aloe latex,
Aloe vera,
drug interactions,
herb interactions